RESEARCH PAPERS - Clinical Manifestations
Cluster-Analytic Identification of Clinically Meaningful Subtypes in MCAS: The Relevance of Heat and Cold
Tinus Häder, Gerhard J Molderings, Frank Klawonn, Rupert Conrad, Martin Mücke, Julia Sellin (2023). This study is the first to perform a cluster analysis of MCAS patients, classifying them into subgroups based on symptoms and triggers, which could help to personalize treatment and improve patient care. The study concludes that there is utility of a cluster analytic approach and the potential of association analysis to improve the understanding of MCAS subtypes and to personalize the therapy.
Learned cautions regarding antibody testing in mast cell activation syndrome
Lawrence B. Afrin, Tania T. Dempsey and Gerhard J. Molderings (2023). This article discusses the role and limitations of antibody testing in MCAS patients. As MCAS causes abnormal antibody production, it can mimic antibodies that can lead to diagnostic confusion and misdiagnosis of autoimmune or infectious diseases. The article suggests that healthcare professionals should exercise caution with positive antibody test results in MCAS patients. It states that the monitoring of clinical symptoms and repeated testing over time should be used to avoid misdiagnosis caused by misleading results.
Health-related quality of life and health literacy in patients with systemic mastocytosis and mast cell activation syndrome
Tobias Jürgen Schmidt, Julia Sellin, Gerhard J Molderings, Rupert Conrad, Martin Mücke (2022). This article assesses the health-related quality of life (HRQOL) and health literacy of people suffering from Systemic Mastocytosis (SM) and Mast Cell Activation Syndrome (MCAS). It finds that SM and MCAS have a significant impact on the quality of life of individuals, and patients with SM typically receive significantly more information from physicians about their disease. Their results demonstrate the importance of patients’ level of information, as even slight improvements in health literacy can have a positive effect on their quality of life.
Safety of COVID-19 vaccination in patients with mastocytosis and monoclonal mast cell activation syndrome
Rayan Kaakati, Dilawar Khokhar, Cem Akin (2021).
mRNA COVID-19 vaccine is well tolerated in patients with cutaneous and systemic mastocytosis with mast cell activation symptoms and anaphylaxis
Tiago Azenha Rama, André Moreira, Mariana Castells (2021).
Persistent Antiphospholipid Antibodies, Mast Cell Activation Syndrome, Postural Orthostatic Tachycardia Syndrome and Post-COVID Syndrome: 1 Year On
Jill R Schofield (2021)
Mast Cell Activation Syndrome: A Primer for the Gastroenterologist
Mast Cell Activation Syndrome: A Primer for the Gastroenterologist Leonard B. Weinstock, Laura A. Pace, Ali Rezaie, Lawrence B. Afrin & Gerhard J. Molderings
Mast cell activation syndrome: Myths and realities
Zhang S, Bernstein JA. Mast cell activation syndrome: Myths and realities. Allergy Asthma Proc. 2021;42(3):198-204. doi:10.2500/aap.2021.42.210012
A case of neuropathic pain in monoclonal mast cell activation syndrome
Bay JL, Sedarsky KE, Petersen MM. A case of neuropathic pain in monoclonal mast cell activation syndrome. Ann Allergy Asthma Immunol. 2018;120(5):543-544. doi:10.1016/j.anai.2018.02.019
Gastrointestinal Involvement in Mast Cell Activation Disorder
Hsieh FH. Gastrointestinal Involvement in Mast Cell Activation Disorders. Immunol Allergy Clin North Am. 2018;38(3):429-441. doi:10.1016/j.iac.2018.04.008
A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome
Qureshi AA, Friedman AJ. A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome. J Drugs Dermatol. 2019;18(2):162-168.
Mast Cell Activation Syndrome: is Anaphylaxis part of the phenotype?
Sabato V, Michel M, Blank U, Ebo DG, Vitte J. Mast cell activation syndrome: is anaphylaxis part of the phenotype? A systematic review [published online ahead of print, 2021 Jul 20]. Curr Opin Allergy Clin Immunol. 2021;10.1097/ACI.0000000000000768. doi:10.1097/ACI.0000000000000768
Fatal anaphylaxis following a hornet sting in a yellow jacket venom-sensitized patient with undetected monoclonal mast cell activation syndrome and without previous history of a systemic sting reaction
Blank S, Pehlivanli S, Methe H, et al. Fatal anaphylaxis following a hornet sting in a yellow jacket venom-sensitized patient with undetected monoclonal mast cell activation syndrome and without previous history of a systemic sting reaction. J Allergy Clin Immunol Pract. 2020;8(1):401-403.e2. doi:10.1016/j.jaip.2019.06.021
Idiopathic Anaphylaxis: A Form of Mast Cell Activation Syndrome
Giannetti MP, Akin C, Castells M. Idiopathic Anaphylaxis: A Form of Mast Cell Activation Syndrome. J Allergy Clin Immunol Pract. 2020;8(4):1196-1201. doi:10.1016/j.jaip.2019.10.048
Tinnitus in MCAS
Weinstock LB, Brook JB, Blasingame KE, Kaleem Z, Afrin LB, et al. (2021) Tinnitus in mast cell activation syndrome: A prospective survey of 114 patients. J Otolaryngol Neurotol Res, 4(1): 92-96.
White matter abnormalities are also repeatedly present in patients with systemic mast cell activation syndrome
Haenisch B, Molderings GJ. White matter abnormalities are also repeatedly present in patients with systemic mast cell activation syndrome. Transl Psychiatry. 2018;8(1):95. Published 2018 May 10. doi:10.1038/s41398-018-0143-5
Mast Cell Activation Syndrome Masquerading as Agranulocytosis
Afrin LB. Mast cell activation syndrome masquerading as agranulocytosis. Mil Med. 2012;177(1):113-117. doi:10.7205/milmed-d-11-00111
Idiopathic Mast Cell activation syndrome With associated salicylate Intolerance
Rechenauer T, Raithel M, Götze T, et al. Idiopathic Mast Cell Activation Syndrome With Associated Salicylate Intolerance. Front Pediatr. 2018;6:73. Published 2018 Mar 27. doi:10.3389/fped.2018.00073
Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases
Afrin LB, Pöhlau D, Raithel M, et al. Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases. Brain Behav Immun. 2015;50:314-321. doi:10.1016/j.bbi.2015.07.002
Mast cell activation syndrome in pregnancy, delivery, postpartum and lactation: a narrative review
Dorff SR, Afrin LB. Mast cell activation syndrome in pregnancy, delivery, postpartum and lactation: a narrative review. J Obstet Gynaecol. 2020;40(7):889-901. doi:10.1080/01443615.2019.1674259
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