Articles
Serum mast cell tryptase measurements: Sensitivity and specificity for a diagnosis of anaphylaxis in emergency department patients with shock or hypoxaemia
Francis A, Fatovich DM, Aren. Serum mast cell tryptase measurements: Sensitivity and specificity for a diagnosis of anaphylaxis in emergency department patients with shock or hypoxaemia. Emerg Med Australas. 2017 Nov 2.
A Practical Guide for Treatment of Pain in Patients with Systemic Mast Cell Activation Disease
Wirz S, Molderings GJ. A Practical Guide for Treatment of Pain in Patients with Systemic Mast Cell Activation Disease. Pain Physician. 2017 Sep;20(6):E849-E861.
"New" tests for MCAS available in the UK
Sheffield Protein Reference Unit tests for mast cell activation markers
Mast cell activation syndromes
Akin C. Mast cell activation syndromes. J Allergy Clin Immunol. 2017 Aug;140(2):349-355. PMID: 28780942 DOI: 10.1016/j.jaci.2017.06.007
Characterization of Mast Cell Activation Syndrome
Mast cell activation syndrome (MCAS), a recently recognized nonneoplastic mast cell disease driving chronic multisystem inflammation and allergy, appears prevalent and thus important. We report the first systematic characterization of a large MCAS population.
Mast cell disorders in Ehlers-Danlos syndrome
This report reviews basic biology of mast cells and mast cell activation as well as recent research efforts, which implicate a role of MC dysregulation beyond atopic disorders and in a cluster of Ehlers-Danlos Syndromes, non-IGE mediated hypersensitivity disorders, and dysautonomia.
Info on Recent International Disease Code (ICD10) codification of MCAS
The coding of MCAS into the ICD-10 (American version) is an important step in gaining better recognition of MCAS.
Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects.
Molderings GJ, Meis K, Kolck UW et al. Comparative analysis of mutation of tyrosine kinase kit in mast cells from patients with systemic mast cell activation syndrome and healthy subjects. Immunogenetics. 2010 Dec;62(11-12):721-7.
NIH Video, scientists uncover genetic explanation for frustrating syndrome
Scientists at the National Institutes of Health have identified a genetic explanation for a syndrome characterized by multiple frustrating and difficult-to-treat symptoms.Most, but not all, people who experience these diverse symptoms have elevated levels of tryptase
Elevated basal serum tryptase identifies a multisystem disorder
JJ Lyons et al. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Nature Genetics DOI: 10.1038/ng.3696 (2016).
Transgenerational transmission of systemic mast cell activation disease-genetic and epigenetic features
Molderings GJ. Transgenerational transmission of systemic mast cell activation disease-genetic and epigenetic features. Transl Res. 2016 Aug;174:86-97
Dr L Afrin Presents on MCAS to the EDS community
A comprehensive presentation covering the history of MCAS as well as presentation, diagnosis and treatment
Pharmacological treatment options for mast cell activation
Molderings GJ, Haenisch B, Brettner S et al. Pharmacological treatment options for mast cell activation. Naunyn Schmiedebergs Arch Pharmacol. 2016 Jul;389(7):671-94
Successful treatment of mast cell activation syndrome with sunitinib
Afrin LB, Cichocki FM, Patel K et al. Successful treatment of mast cell activation syndrome with sunitinib. Eur J Haematol. 2015 Dec;95(6):595-7
Utility of Continuous Diphenhydramine Infusion in Severe Mast Cell Activation Syndrome
Lawrence B Afrin; Utility of Continuous Diphenhydramine Infusion in Severe Mast Cell Activation Syndrome; Blood 2015 126:5194
Utilities of Various Mast Cell Mediators in Diagnosing Mast Cell Activation Syndrome
Nicolas Zenker and Lawrence B Afrin,Utilities of Various Mast Cell Mediators in Diagnosing Mast Cell Activation Syndrome Blood 2015 126:5174
H1-antihistamines for primary mast cell activation syndromes: a systematic review
4 Nurmatov UB, Rhatigan E, Simons FE, Sheikh A. H1-antihistamines for primary mast cell activation syndromes: a systematic review. Allergy. 2015;70(9):1052-61.
Mast Cells, Mastocytosis, and Related Disorders
Theoharides TC, Valent P, Akin C. Mast Cells, Mastocytosis, and Related Disorders. N Engl J Med. 2015;373(2):163-72.
Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases.
Afrin LB, Pöhlau D, Raithel M et al. Mast cell activation disease: An underappreciated cause of neurologic and psychiatric symptoms and diseases. Brain Behav Immun. 2015 Nov;50:314-21.
Mast cell activation syndromes presenting as anaphylaxis
3 Akin C . Mast cell activation syndromes presenting as anaphylaxis. Immunol Allergy Clin North Am. 2015 May;35(2):277-85.
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